Bio Reactors

These reactors were designed for ease of use and sterilization through placing directly into an autoclave.

There are three main classes of reactors which will fall into the following categories:

Jacketed reactors for mostly aerobic sterile fermentations.

Un-jacketed reactors for mostly photo sensitive processes.

Air lift bio reactors for various applications.

All of these units have the option of the following peripherals.

Our units are from 1L up to 20L capacity and can have the following peripherals.

Stirring via a stainless steel bearing system which is sealed from the liquid via a special PTFE packing gland. This bearing can be autoclaved with the reactor. The motor easily dismounts from the lid and can be mounted after the autoclave process is done. All our units use brushless dc stirring motors with very accurate speed control in order to monitor small viscosity changes which in turn is logged. The stirrers are made with variable pitch blades and multiple stirrers can be mounted on the stirring shaft.

Measure and control ph from ph2—ph14.

Sparging of air via either a stainless steel 10 micron filter , or a 16 micron glass filter. Air flow can be measured via a rotameter.

Measure dissolved oxygen. Control can be added if needed.

Temperature control via either a hot oil/water circulator, heating mantle or water bath.

The reactors can be dismounted from the system in order to autoclave with the media in place. The most economical way is to sterilize and insert the Ph, DO and temp probes after the autoclave process. We can source probes which can survive the autoclave process, but they are much more expensive.

Logging of all data on a SD card on a .CSV format.

Liquid addition can be done via either a peristaltic pump , or a highly accurate syringe pump.

All the electronic units connected to the reactor communicates via CAN BUS protocol and all data can be logged.

Sampling can be done from either the top of the lid or with an added port at the bottom of the reactor with a septum.

A cooling condenser with a controlled servo valve is available , should cooling be needed during the fermentation. The cooling temperature can be selected from the hot oil circulator. Due to the condenser, the cooling water is isolated from the heating fluid.